MIF shows profibrotic properties after MCD diet via NKT cell population
D Heinrichs, M Knauel, ML Berres, P Fischer, C Trautwein, HE Wasmuth, J Bernhagen · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory cytokine. It has recently been recognized to function as a chemokine-like molecule in chronic inflammatory diseases. In a model of hepatotoxic liver injury, MIF shows anti-fibrotic properties via CD74 and AMPK. In a model of non-alcoholic steatohepatitis, MIF has anti-steatotic properties. Because NASH is also associated with fibrosis within the liver, we compared Mif -/- with wild-type mice in an experimental liver fibrosis and metabolic disease model. Methods: Mif -/- and wild-type mice were fed a methionine- and choline def…
