CareLit Fachartikel
A new modelling approach for Gli transcription factor network in hepatocytes
M Matz-Soja, W Schmidt-Heck, R Guthke, R Gebhardt · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Dokument
1083808
CareLit-ID
Jahr
2015
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Morphogenetic pathways, like the Wnt and Hedgehog are complex systems which organize important processes during development and adulthood. In most of these pathways, positive and negative feedback loops are of considerable importance, because they influence and/or modulate the dynamic behaviour of these pathways. Usually, feedback loops are part of the signalling pathway itself based on the interaction of downstream components (e.g. target gene products) with upstream components in circuits of variable length. In the case of vertebrate Hh signalling the 3 Gli proteins Gli1, Gli1 and Gli3 act as transcriptional a…
Schlagworte
Network
Feedback
Hepatocytes
Signalling
Sirna
Fuzzy
System
Pathways
Negative
Target
Factors
Regulatory
Zeitschrift für Gastroenterologie
