Representation of human non-alcoholic fatty liver disease in murine models
A Teufel, T Itzel, W Erhart, M Brosch, YO Kim, W von Schönfels, A Herrmann, S Brückner, F Stickel, T Chavakis, C Hellerbrand, T Becker, S Schreiber, D Schuppan, C Schafmeier, J Hampe · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries. Murine models are the key mechanistic platform for the disease. We systematically evaluated genome-wide mRNA expression data from five commonly used murine models of NAFLD (high-fat diet, MCD diet, streptozotocin diet, PTEN (Fox) KO) in comparison to human data from 39 controls and 77 NAFLD samples spanning the range of the phenotype. First, profound differences between human and murine expression patterns exist, that override any disease or phenotype signature. In fact, from the significantly regulat…
