CareLit Fachartikel

Mouse models of colorectal and mammary cancer liver metastases and microenvironmental interplay with tumor-associated macrophages (TAMs)

D Bocuk, P Krause, S Niebert, T Pukrop, T Beissbarth, M Ghadimi, S Koenig · Zeitschrift für Gastroenterologie · 2015 · Heft 01

Dokument
1083814
CareLit-ID
Jahr
2015
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
D Bocuk, P Krause, S Niebert, T Pukrop, T Beissbarth, M Ghadimi, S Koenig
Ausgabe
Heft 01 / 2015
Seiten
–
Erschienen: 2015-01-16 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0034-1397186

Zusammenfassung

Introduction: Colorectal cancer (CRC) and breast cancer (BC) rank as two of the most common tumors in developed countries. Given the relatively frequent formation of liver metastases, investigation of the hepatic microenvironment is crucial. Here we present two new immunocompetent mouse models of liver metastases and the microenvironmental interplay of tumor cells with TAMs. Methods: The cancer cell lines 410.4 (mammary gland) and CMT-93 (colorectal) were implanted locally into the liver or via the portal vein of syngeneic mice to monitor the time-dependent progression into metastases. Immunostaining demonstrate…

Schlagworte

Tumor Beta-Catenin beta Catenin Association Breast Zeitschrift für Gastroenterologie