CareLit Fachartikel
CEACAM1 deficiency exacerbates acute liver injury in a mouse model of immune-mediated hepatitis
C Wegscheid, AK Horst, G Tiegs · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Dokument
1083816
CareLit-ID
Jahr
2015
Publikation
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Metadaten
DOI
ja
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Zusammenfassung
* equal contribution Introduction: Injection of a sublethal dose of the T cell mitogenic plant lectin concanavalin A (ConA) induces acute immune-mediated liver injury. Hallmarks of liver injury are increased plasma transaminase activities and the release of pro-inflammatory cytokines. CEACAM1 is a cellular adhesion molecule that is expressed on epithelia, endothelia, and leukocytes. Originally, CEACAM1 has been identified as an intercellular homophilic adhesion molecule on hepatocytes. The CEACAM1 isoform with a long cytoplasmic domain contains an immune receptor tyrosine-based inhibition motif (ITIM) that is pi…
Schlagworte
After
Cytokines
Concanavalin A
Observation
Hepatitis
Zeitschrift für Gastroenterologie
