Migration of Human Monocytes is stimulated by Jagged-1 and DLL-4 via the Notch Pathway

The Notch signaling pathway is a well-conserved signaling pathway. As known so far Notch signaling is engaged in physiological processes in lung cancer and pulmonary hypertension (PAH). As shown recently, a significant increase of perivascular numbers of macrophages (CD68(+) and monocytes (CD14(+) can be observed in PAH. The aim of this study was to elucidate the role of the Notch signaling pathway in the migration of human monocytes. Human monocytes were isolated from venous blood, taken from healthy donors. For the chemotactic assays modified 48-well microchemotaxis chambers were used. Cells migrated through a…