IL-37 requires IL18Rα and SIGIRR/IL-1R8 to ameliorate experimental allergic asthma in mice

Background: The new cytokine interleukin (IL) 37 has been described as negative regulator of innate immunity. It reduces activation of DCs and the production of pro-inflammatory mediators in murine and human immune cells. Recently, results from the CLARA childhood asthma cohort suggested an impact of IL-37 on human asthma pathogenesis. This study aimed to clarify, whether IL-37 also provides anti-inflammatory effects on adaptive immune responses and, through which receptor it exerts its effects. Methods: IL-37 levels in supernatants of restimulated peripheral blood mononuclear cells isolated from asthmatic and h…