The inhibition of soluble epoxide hydrolase protects from retinal vasoregression

Background: Retinal vasoregression is a hallmark of diabetic retinopathy. Inflammatory responses, in particular from microglia, are involved in retinal degeneration. Recruitment and activation of microglia are regulated by Notch signaling and lipid metabolic products. Retinal vessel maturation and quiescence as well as mural cell recruitment are also linked to Notch signaling. Recently, a critical role of sEH in regulation of vascular formation and inflammatory biology was described. Moreover, ω-3 polyunsaturated fatty acids (PFA) can attenuate early retinal degeneration. However, the role of sEH in retinal vaso…