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Carnosinase concentration and activity in CNDP1 (CTG)5 homozygous T2DM patients with and without nephropathy

S Zhang, F Pfister, H Lindner, T Albrecht, S Classen, S Kabtni, V Peters, C Klessens, J van den Born, G Navis, S Bakker, E de Heer, B Krämer, B Yard, S Hauske · Diabetologie und Stoffwechsel · 2015 · Heft 04

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1084116
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Jahr
2015
Publikation
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DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
S Zhang, F Pfister, H Lindner, T Albrecht, S Classen, S Kabtni, V Peters, C Klessens, J van den Born, G Navis, S Bakker, E de Heer, B Krämer, B Yard, S Hauske
Ausgabe
Heft 04 / 2015
Seiten
–
Erschienen: 2015-04-29 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0035-1549666

Zusammenfassung

This study assessed if serum carnosinase (CN-1) activity, concentration and conformation in Type 2 diabetes mellitus (T2DM) patients carrying the protective CNDP1 genotype ((CTG)5 homozygous) with diabetic nephropathy (DN) differ from those without nephropathy. In a cross-sectional design 127 T2DM patients with DN and 145 T2DM patients without nephropathy were recruited. Additional control groups, i.e, non- diabetic controls (n = 111) and uraemic controls (n = 85) were included for assessing confounders. CNDP1 (CTG)5 homozygous T2DM patients with DN had significantly lower CN-1 concentrations (30.4 ± 18.3 vs. 51…

Schlagworte

Albuminuria Diabetes Mellitus Diabetologie und Stoffwechsel