Oxidative stress is a driver of chromosomal instability and tumorigenesis in IL-10KO mice

Patients with inflammatory bowel disease like Crohn's disease (CD) and ulcerative colitis (UC) have a higher risk of developing colitis-associated cancer (CAC); however, the underlying mechanism of disease progression from colitis to CAC is not well understood. IL-10 and IL-10R polymorphism are implicated by GWAS studies in susceptibility for UC. In inflammation-driven carcinogenesis, genetic instability and oncogenic signaling can be driven by perpetual oxidative stress. Here we investigated cellular processes implicated in colon carcinogenesis in a mouse model of CAC. Genetic and epigenetic mechanisms involved…