Influence of Lactobacillus casei Shirota supplementation, insulin resistance and diet on gut microbiota, gut permeability and bile acid profile in patients with metabolic syndrome
B Leber, V Stadlbauer, S Lemesch, S Trajanoski, M Bashir, A Sinnitsch, A Horvath, M Tawdrous, T Stojakovic, G Fauler, P Fickert, C Högenauer, I Klymiuk, P Stiegler, M Lamprecht, T Pieber, N Tripolt, H Sourij · Zeitschrift für Gastroenterologie · 2015 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Metabolic syndrome (MetS) is associated with disturbances in gut microbiota. In animal models, modulation of gut microbiota by probiotic supplementation is possible. However, data in humans are scarce and controversial. Aim: To study whether probiotic supplementation, insulin resistance (IR) or diet impact on gut microbiota composition, gut barrier integrity and inflammation or bile acid profile in MetS. Methods: In a single-centre, prospective, randomised controlled pilot study, 28 subjects with MetS received either Lactobacillus casei Shirota (LcS) for 12 weeks (n = 13) or no LcS (n = 15). Data wer…
