Efficacy of interferon-free all-oral regimens in the treatment of chronic Hepatitis C outside from clinical trials – a “real life experience”

Background: Phase-III studies with interferon-free all-oral regimens have yielded SVR12-rates exceeding 90%. The aim of this study was to assess, whether these excellent results can be reproduced outside from clinical trials in difficult-to-treat patients with advanced liver disease in a “real-life-setting”. Patients and Methods: A total of 97 patients, who started treatment with an all-oral regimen outside from clinical trials at our outpatient clinic between 20.6.2014 and 10.3.2015, were included. The study population comprised 62 males and 35 females (mean age: 55 ± 22 years). The frequency of genotypes (GT)…