CareLit Fachartikel

Cigarette smoke exposure enhances obstructive bronchitis in ENaC overexpressing newborn-mice

J Jia, TM Conlon, C Ballester Lopez, O Eickelberg, MA Mall, AÖ Yildirim · Pneumologie · 2015 · Heft 05

Dokument
1084274
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
J Jia, TM Conlon, C Ballester Lopez, O Eickelberg, MA Mall, AÖ Yildirim
Ausgabe
Heft 05 / 2015
Seiten
–
Erschienen: 2015-05-13 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0035-1551906

Zusammenfassung

Chronic bronchitis (CB) is characterized by mucus accumulation, airway neutrophilia, and chronic airway obstruction. Excess mucus production, together with less efficient cough and loss of normal ciliary function, leads to recurrent airflow limitation, airway remodeling and respiratory obstruction. Overexpression of Na+ ion channels (βENaC) in the airway epithelial membrane of mice leads to airway surface liquid depletion and mucocilia clearance dysfunction, resulting in airway mucus accumulation and subsequent COPD-like disease (Mall et al. AJRCCM 2008). Cigarette smoke exposure is recognized to be the major fa…

Schlagworte

Bronchitis Bronchoalveolar Lavage Fluid Bronchoalveolar Lavage Airway Obstruction Airway Remodeling Goblet Cells Pneumologie