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Identification of novel loci associated with respiratory disease by a forward genetic approach in mouse

W Yin, HT Kim, Z Jaberansari, C Buettner, DYR Stainier · Pneumologie · 2015 · Heft 07

Dokument
1084399
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
W Yin, HT Kim, Z Jaberansari, C Buettner, DYR Stainier
Ausgabe
Heft 07 / 2015
Seiten
–
Erschienen: 2015-07-14 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0035-1556636

Zusammenfassung

The objective of this research is to help elucidate the genetic causes and developmental mechanisms of respiratory disease. A large-scale ethylnitrosourea (ENU) mutagenesis forward genetic screen is being carried out to identify regulators of lung cell differentiation, alveolar morphogenesis, pulmonary vascular development as well as tracheal cartilage ring formation. We have screened 157 C57BL/6J F1 animals for recessive phenotypes at P7, and are currently trying to recover at least 51 potential respiratory disease mouse models including emphysema, pneumonia, alveolar capillary dysplasia (ACD), idiopathic pulmo…

Schlagworte

Pulmonary Respiratory Disease These Genetic Screen Being Identify Alveolar Development Phenotypes Genes Pneumologie