Distinct temporal regulation of NFATc1 activity safeguards proper regeneration of the exocrine pancreas
E Heßmann, N Chen, A König, M Dyck, T Winter, C Lubeseder-Martellato, J Siveke, A Neeße, V Ellenrieder · Zeitschrift für Gastroenterologie · 2015 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: In response to acute pancreatitis, surviving acinar cells transiently dedifferentiate and repopulate the exocrine compartment or persist in a metaplastic state that eventually triggers pancreatic atrophy and exocrine insufficiency. Recent evidence suggests that developmental and inflammatory transcription factors effectively control the pancreatic regeneration program. Aim: To characterize the regulation and function of the inflammatory transcription factor NFATc1 in pancreatic regeneration. Materials & methods: Caerulein was used to induce acute pancreatitis in various pancreas specific transgenic m…
