Short-term vitamin D supplementation improves hepatic steatosis as quantified by controlled attenuation parameter (CAP)

Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries. A recent meta-analysis has confirmed decreased serum 25-hydroxyvitamin D levels in patients with NAFLD. This intervention study investigates whether vitamin D therapy ameliorates hepatic steatosis in patients referred to the outpatient liver clinic of a tertiary centre. Methods: We prospectively recruited 40 patients with NAFLD and vitamin D deficiency, as defined by serum concentrations. Results: Overall, the cohort comprised 47.5% women (mean age 54.9 ± 12.1 years; mean BMI 29.5 ± 3.0…