Cell culture models of pediatric high-grade glioma are susceptible to parvovirus-1 induced cytotoxicity
R Josupeit, S Bender, B Leuchs, C Herold-Mende, JR Schlehofer, O Witt, J Rommelaere, J Jeannine Lacroix · Klinische Pädiatrie · 2015 · Heft 11
Bibliografische Angaben
Zusammenfassung
Oncolytic viruses have entered the field of pediatric clinical research with the first early phase clinical trial recently published. Based on promising pre-clinical studies, the oncolytic parvovirus H-1 (H-1PV) has been applied to adult glioblastoma patients in a phase I/IIa clinical trial, indicating clinical safety of intracranial and intravenous virus application. Here, we characterized the cytotoxic effects induced by the oncolytic parvovirus H-1 in conventional pediatric high-grade glioma (HGG) cell culture models and neurosphere cultures derived thereof. Adherent cultures derived from diffuse intrinsic po…
