A pro-inflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis
K Karimi, K Neumann, J Meiners, R Voetlause, W Dammermann, S Lüth, C Wegscheid, A Horst, G Tiegs · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Type 2 innate lymphoid cells (ILC2) mediate inflammatory immune responses in the context of diseases triggered by the alarmin IL-33. We observed high levels of IL-33 in serum of patients with acute hepatitis B infection, suggesting a role for this cytokine in disease pathogenesis. However, the immunoregulatory functions of ILC2 s and IL-33 in immune-mediated hepatitis are less clear. Using the murine model of Concanavalin (Con)A-induced immune-mediated hepatitis, we showed that elevated hepatic IL-33 expression was associated with severe liver inflammation. Interestingly, ILC2 s expressing the IL-33 receptor ST2…
