CareLit Fachartikel
Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain- and MK2-dependent manner resulting in LCN2 suppression
S Stindt, S Spitzley, R Bartenschlager, D Häussinger, JG Bode · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Dokument
1084775
CareLit-ID
Jahr
2015
Publikation
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Background: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide, leading to end-stage cirrhosis and development of hepatocellular carcinoma. To achieve persistence, the virus has evolved several strategies to modulate the inflammatory response, cell proliferation, differentiation and prevent apoptosis. Here, we investigated the influence of HCV-mediated downregulation of the atypical member of the inhibitor of κB protein family IκBζ in response to IL-1β stimulation and its functional consequences focusing on LCN2 deregulation. Methods: Huh7 cells either infected with the HCVcc s…
Schlagworte
Calpain
Hepatitis
Association
Apoptosis
Cytokine
Zeitschrift für Gastroenterologie
