IL-37 ameliorates experimental asthma via a mechanism that is independent from IL-18 signaling

Study objectives: IL-37 has been described as a negative regulator of innate immunity. Production of IL-37 is impaired in allergic asthmatics suggesting a role for IL-37 in asthma pathogenesis. We could demonstrate that IL-37 ameliorates experimental asthma via a mechanism that requires IL-18Rα and SIGIRR. This study is aimed to further clarify, how these effects on asthma pathogenesis are mediated. Methods: Experimental asthma was induced in IL-18Rβ-deficient and MyD88-deficient mice. IL-37 was applied intratrachealy during allergen challenge. Infiltration of eosinophiles, lung inflammation, mucus production an…