External muscle stimulation differentiates circulating hematopoietic stem cells in diabetes patients
I Spanidis, A Hidmark, T Fleming, N Volk, V Eckstein, JB Gröner, S Kopf, PP Nawroth, D Oikonomou · Diabetologie und Stoffwechsel · 2016 · Heft 04
Bibliografische Angaben
Zusammenfassung
Introduction: External electric muscle stimulation (EMS) can reduce pain resulting from diabetic neuropathy (DN), a vascular complication of diabetes. It was hypothesized that EMS-treatment activated circulating CD34+ hematopoietic stem cells (HSC), which can participate in vessel repair by differentiating into endothelial progenitor cells (EPC). Methods: 24 DN patients were evaluated for neuropathic symptoms using Diabetic Neuropathy Symptom Score (NSS) and Neuropathy Disability Score (NDS) after three 60 minutes EMS-treatments. The frequency of CD34+ HCS and expression of surface markers were determined by flo…