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Genome wide meta-analysis identifies novel regulators of circulating serum progranulin

J Krüger, M Scholz, A Gross, K Krause, C Marzi, H Grallert, C Ladenvall, D Schleinitz, H Kirsten, H Heyne, E Laurila, J Kriebel, B Thorand, W Rathmann, L Groop, I Prokopenko, B Isomaa, F Beutner, J Kratzsch, J Thiery, N Klöting, A Fischer-Rosinský, A Pfeiffer… · Diabetologie und Stoffwechsel · 2016 · Heft 04

Dokument
1084930
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Jahr
2016
Publikation
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
J Krüger, M Scholz, A Gross, K Krause, C Marzi, H Grallert, C Ladenvall, D Schleinitz, H Kirsten, H Heyne, E Laurila, J Kriebel, B Thorand, W Rathmann, L Groop, I Prokopenko, B Isomaa, F Beutner, J Kratzsch, J Thiery, N Klöting, A Fischer-Rosinský, A Pfeiffer…
Ausgabe
Heft 04 / 2016
Seiten
–
Erschienen: 2016-04-19 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0036-1580916

Zusammenfassung

Background: Progranulin is a secreted protein with important functions in processes including immune and inflammatory response and embryonic development. Genetic factors determining progranulin concentrations are yet unknown. Material and methods: We conducted a meta-analysis of genome-wide association studies (GWAS) for serum progranulin in three independent cohorts from Europe: Sorbs and KORA from Germany and PPP-Botnia from Finland (total N = 2,791). All SNPs associated with progranulin levels were genotyped for replication in 2 additional cohorts: LIFE Heart Study (N = 967) and Berlin cohort (Metabolic Syndr…

Schlagworte

Diabetologie und Stoffwechsel