A novel orthotopic mouse model in sarcomas

Introduction: Pediatric sarcomas are a heterogeneous group of bone and soft tissue malignancies affecting children and young adults. Some of these highly aggressive tumors of mesenchymal origin harbor a characteristic chromosomal translocation. One of the most important prognostic factors of those diseases is the presence of metastasis at diagnosis. In that context, we have developed a novel orthotopic model, which can be used both for the study of spontaneous metastasis and also for evaluating therapeutic index in the onset of metastasis. Methods: Orthotopic mouse model. Results: This new model consists in inje…