Lipocalin2 deficiency results in colitis exacerbation and tumor development in IL-10 mice by Alistipes overgrowth

Introduction & Aims: Accumulating evidence suggests that the intestinal microbiota plays a key role in the initiation and progression of colitis and furthermore colitis associated cancer (CAC). Host factors promoting or preventing disease are a matter of intense research. The protein Lipocalin2 (Lcn2) is highly upregulated during inflammatory conditions and inhibits bacterial growth by sequestration of siderophore-bound iron. However its impact on gut immunity and on the microbiota during intestinal inflammation remains unclear. In this study we investigated the functional contribution of Lcn2 in the colon and i…