Gut permeability and neutrophil function in secondary sclerosing cholangitis of critically ill patients
M Tawdrous, A Horvath, B Schmerböck, B Leber, A Hartl, W Spindelböck, G Fauler, T Stojakovic, P Stiegler, V Stadlbauer · Zeitschrift für Gastroenterologie · 2016 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Secondary sclerosing cholangitis of critically ill patients (SSC-CIP) is a chronic progressive disease of the biliary tract. Consequences are cholestasis, infections and the development of biliary cirrhosis. The cause of SSC-CIP is unclear and a cure can only be achieved through liver transplantation. We hypothesize that altered gut permeability may be a reason for the development of SSC-CIP that induces an altered innate immune system. Methods: Patients with SSC (n = 10) and healthy controls (n = 21) were investigated. Serum bile acids (assessed as unconjugated acids, taurine and glycine conjugates)…
