Role of autophagy in adipose tissue and in peripheral nervous system in diabetes type 2, obesity and metabolic syndrome
J Kosacka, N Klöting, M Nowicki, P Baum, M Stumvoll, S Paeschke, KV Toyka, I Bechmann, M Blüher · Diabetologie und Stoffwechsel · 2016 · Heft 06
Bibliografische Angaben
Zusammenfassung
Background: Pathophysiology of obesity is closely associated with enhanced autophagy in adipose tissue (AT) and in peripheral nerves (PN). Autophagic process can promote survival or activate cell death. Therefore, we examined the occurrence of autophagy in AT of type 2 diabetes (T2D) patients in comparison to obese and lean individuals without diabetes. Moreover, we analysed the autophagy in AT and in peripheral nerves of WOKW rats with metabolic syndrome (MS) compared to LEW.1W control rats. Methodology/principal findings: Numerous autophagosomes accumulated within adipocytes were visualized by electron transmi…
