Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men – an explorative randomized placebo-controlled double blind study

Aims: Considering the negative effects of stress on health and well-being, there is a growing interest to modulate the reactivity of stress response systems. The present study assesses the effects of Ze 185 on psychobiological stress responses in an acute experimental psychosocial stress paradigm. Materials and methods: 72 healthy male participants were randomized to Ze 185 (fixed combination of 4 herbal extracts), placebo or no treatment. 4 days post-baseline, all participants underwent a standardized psychosocial stress paradigm (Trier Social Stress Test) [1]. Participants took either tablets of Ze 185 or plac…