TGF-ß on the loose: How downregulation of BAMBI contributes to perturbed signaling in NSCLC
S Marwitz, S Depner, D Dvornikov, R Merkle, M Szczygieł, K Müller-Decker, P Lucarelli, M Wäsch, H Mairbäurl, KF Rabe, C Kugler, E Vollmer, M Reck, S Scheufele, M Kröger, O Ammerpohl, R Siebert, T Goldmann, U Klingmüller · Pneumologie · 2016 · Heft 07
Bibliografische Angaben
Zusammenfassung
Introduction: Despite recent developments in targeted therapies, non-small cell lung cancer still remains among the most fatal types of cancer. Most patients are diagnosed with an advanced state of the disease and exhibit poor prognosis independent of therapeutic efforts. The TGF-β signaling pathway is known to be involved in several different diseases as well as crucial cellular or immunological processes. Especially in malignant diseases such as lung cancer, the pathway is known to exert a double-edged role. In early stages of carcinogenesis, the tumor suppressive effects prevail, while at later stages invasiv…
