Cigarette Smoke and Cigarette Smoke Condensate Induce Inflammation and Cytotoxicity in Precision-Cut Lung Slices (PCLS)
H Obernolte, D Ritter, J Knebel, P Braubach, D Jonigk, G Warnecke, M Krüger, HG Fieguth, O Pfennig, A Braun, K Sewald · Pneumologie · 2016 · Heft 07
Bibliografische Angaben
Zusammenfassung
COPD is characterised by emphysema, mucus hypersecretion and airway inflammation. COPD is the fourth leading cause of death worldwide. Major reason to develop COPD is cigarette smoke (Cs). Therefore, a human relevant Cs model is needed. Currently several human cell culture models and non-human animal models are well-established. Most are lacking the human microenvironment, which is necessary to induce inflammatory, destructive and cytotoxic effects of Cs. Thus, the project's aim is to establish features of COPD in the 3D model of Precision-Cut Lung Slices (PCLS) of different species by using Cs and cigarette smo…
