Lung function impairment is associated with increased left ventricular cardiac wall stress in COPD: The German multicenter COSYCONET study
P Alter, RA Jörres, H Watz, T Welte, S Gläser, H Schulz, R Bals, A Karch, E Wouters, J Vestbo, D Young, CF Vogelmeier · Pneumologie · 2016 · Heft 07
Bibliografische Angaben
Zusammenfassung
Introduction: Cardiovascular comorbidities are common in patients with COPD and associated with increased morbidity and mortality. Underlying mechanisms are largely unclear. We therefore studied the association between lung hyperinflation, airflow limitation, and left ventricular (LV) function, morphology and wall stress in a comprehensive manner using structural equation modeling (SEM) in a large data set from the COPD cohort COSYCONET. Methods: Within COSYCONET 2,741 patients were recruited. Applying predefined criteria of completeness and quality, a subset of patients underwent baseline evaluations including…
