Coffee consumption promotes survival and protects against hepatocellular carcinoma recurrence following liver transplantation: putative mechanisms involve modulation of adenosiner…
G Wiltberger, R Maio, U Lange, R Ascherl, HM Hau, F Krenzien, G Atanasov, C Benzing, E Tapper, L Feldbrügge, J Broschewitz, M Bartels, S Jonas, J Pratschke, Y Wu, S Robson, M Schmelzle · Zeitschrift für Gastroenterologie · 2016 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: Increasing evidence suggests that coffee consumption might be associated with hepatocellular carcinoma (HCC) and liver cirrhosis death risk. Caffeine is a natural antagonist to extracellular adenosine-mediated receptor signaling with proposed tumoricidal activity in experimental settings. Aim: To determine whether coffee consumption decreases HCC recurrence and promotes survival following orthotopic liver transplantation (OLT) and to examine putative mechanisms of action. Methods: Patients who underwent OLT for HCC from January 2002 to December 2012 were interviewed on consumed cups of coffee per day…
