CareLit Fachartikel
Neolacto glycosphingolipids promote Doxorubicin, Epirubicin, and organoarsenic PENAO sensitivity and hypoxia-induced HIF-1a accumulation in ovarian cancer cells
A Fedier, S Alam, K Winkelbach, R Kohler, V Heinzelmann-Schwarz, F Jacob · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Dokument
1085253
CareLit-ID
Jahr
2016
Publikation
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Introduction/Aim: We investigate the yet unknown function of neolacto-glycosphingolipids GSLs (P1 and nLc4) on drug sensitivity and response to hypoxia, two major obstacles in cancer management. We used parental IGROV1 ovarian cancer cells and our previously generated knockout subline disrupted in B3GNT5 gene (B3GNT5-ko). B3GNT5 is the key enzyme in P1 and nLc4 biosynthesis. GSLs are located on the cell membranes and considered to be critically implicated in the pathogenesis of various diseases and cancer. Material and methods: Gene disruption was achieved by CRISPR/Cas9 genome-editing of B3GNT5 and confirmed by…
Schlagworte
Apoptosis
Anthracyclines
Carboplatin
Cisplatin
Chloride
Cobalt
Geburtshilfe und Frauenheilkunde
