Immunohistochemical analysis of CD56-positive uNK-cells in the endometrium

Recurrent miscarriage (RM) and repeated implantation failure (RIF) are highly frustrating reproductive disorders. Uterine natural killer cells (uNK) form a large portion of immunological cells in the uterine cavity and are major players during implantation and early pregnancy. However, the distribution during the menstrual cycle and the pathophysiological significance in (early) pregnancy is only partially understood. Preliminary evidence indicates that the concentration of uNK cells in women with RM and RIF is increased. The aim was to establish an analytic model in order to quantify uNK cell concentration in t…