Identification and characterization of a specific neuronal calcium sensor protein as novel prognostic and predictive biomarker for ovarian cancer therapy

Sporadic ovarian cancer has the highest relative mortality among gynecological cancers. As early symptoms are nonspecific 75% of patients are diagnosed at an advanced stage leading to poor overall survival. To improve patient's outcome targeted therapy strategies are highly demanded. Thus, in search of new biomarkers for personalized ovarian cancer therapy, we recently identified a gene encoding a specific neuronal calcium sensor (NCS) protein. The NCS-family is mainly known to be involved in calcium-signaling on membranes and functions as calcium dependent molecular switches. Chip-based mRNA expression of the c…