Diagnostic potential of micro RNAs expression profiles in breast and gynecologic cancer
M Hirschfeld, D Weiß, M Jäger, J Asberger, S Mayer, C Nöthling, K Berner, G Gitsch, T Erbes · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Purpose: Various microRNAs act as key regulatory factors in tumorbiological processes, with both, oncogenic as well as tumor suppressive functions. This study focused on the putative biomarker properties of 24 microRNA types, investigated in three breast cancer (BC), endometrial cancer (EC) and ovarian cancer (OC) in vitro models, respectively, to determine their diagnostic potential. Material and methods: The expression pattern of 24 microRNA specimen were investigated in three established BC, EC and OC cell lines, respectively. Quantitative analysis was performed by RNA isolation and subsequent realtime PCR. T…
