First steps towards a targeted immunomodulatory therapy in patients with recurrent miscarriage and elevated natural killer cells

Objective: Elevated peripheral and uterine NK cells (pNK, uNK) are associated with recurrent miscarriage (RM). Intralipids have been proposed as a treatment option to modulate NK cell dysbalance in RM patients. The aim of this study was to identify immune parameters that might predict treatment success in RM patients with elevated NK cells. Materials and methods: In total, n = 23 RM patients with 33 RM and elevated NK cells (n = 12 elevated pNK, n = 13 elevated uNK; n = 2 with elevation in both parameters) were treated with intralipids following a standardized treatment protocol. Intralipid therapy (8 ml 20% Int…