Simultaneously double infection of oncolytic viruses leads to addition of cell death induction in glioblastoma cell lines

Malignant glioblastomas are highly aggressive tumors virtually resistant to available treatments and predominantly leading to death. A promising new therapeutic strategy is virotherapy with oncolytic viruses, which have the ability to kill different forms of tumor cells. For three of such viruses (Reovirus, RV; Parvovirus-H, PV and Newcastle-Disease-Virus, NDV) a strong tumorlytic effect on glioma cells is described in vitro and in animal models. It is known that the viruses can induce different kinds of cell death, like apoptosis or necroptosis, via different pathways. To investigate the oncolytic capacity and…