CareLit Fachartikel
Prognostic and Biological Role of Neurotrophin- Receptor TrkA and TrkB in Neuroblastoma
A. Eggert, N. Ikegaki, Xing-ge Liu, G. M. Brodeur · Klinische Pädiatrie · 2000 · Heft 04 · S. 200-205
Dokument
1099311
CareLit-ID
Jahr
2000
Publikation
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Zusammenfassung
Abstract: Expression of different neurotrophin receptors of the tyrosine kinase (Trk) family plays an important role in the biology and clinical behavior of neuroblastomas (NB). Observations from several independent studies suggest that high expression of TrkA is present in NB with favorable biological features and highly correlated with patient survival, whereas TrkB is mainly expressed on unfavorable, aggressive NB with MYCN-amplification. To determine expression of Trk receptors and ligands in primary NB, we developed a reliable semiquantitative duplex RT-PCR protocol, that requires only 1 μg RNA per tumor sa…
Schlagworte
Neuroblastoma
tyrosine kinase receptors
neurotrophins
proliferation
differentiation
Neuroblastom
Tyrosinkinase-Rezeptor
Neurotrophine
Differenzierung
Abbreviations
Biology
Tumor
Klinische Pädiatrie
