CareLit Fachartikel
Brimonidine and inhibition of nitrite production in isolated porcine ciliary processes
Rong Liu, Josef Flammer, Ivan O. Haefliger · Klinische Monatsblätter für Augenheilkunde · 2001 · Heft 05 · S. 348-350
Dokument
1099472
CareLit-ID
Jahr
2001
Publikation
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Metadaten
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Bibliografische Angaben
Zusammenfassung
Abstract PURPOSE To investigate whether the α2-adrenoreceptor agonist brimonidine (a drug that decreases intraocular pressure in part by reducing aqueous humor production) can inhibit the production of nitrite induced by forskolin in isolated porcine ciliary processes. METHODS Nitrite (a metabolite of nitric oxide) was measured (Griess reaction) before and two hours after exposure to the adenylcyclase activator forskolin (0.1 μM) in the presence or in the absence of the brimonidine (10 μM) and/or the α2-adrenoreceptor antagonist yohimbine (10 μM). RESULTS The increase of nitrite production evoked by forskolin (1…
Schlagworte
Glaukom
Neuroprotektion
Exzitotoxizität
Anionenströme
Chloridkanäle
Ziliarkörperepithel
β-Blocker
Glaucoma
neuroprotection
excitotoxicity
anionic currents
chloride channels
ciliary epithelium
β-blockers
Adenylcyclase
After
