Bedeutung persistenter Organochlorverbindungen in der Pathogenese des Mammakarzinoms
M. Bauer, F. Hilpert, I. Meinhold-Heerlein, W. Jonat · Geburtshilfe und Frauenheilkunde · 2004 · Heft 07 · S. 681-689
Bibliografische Angaben
Zusammenfassung
Abstract The role of persistent organochlorine compounds in the development of breast cancer is controversially discussed. Used as biocides or technical adjuvants for miscellaneous applications, organochlorines have been released into the environment for years. Due to their highly lipophilic properties, they have been able to accumulate in the food chain leading to a long lasting presence in human tissues. The evidence that organochlorines might be involved in the carcinogenesis of breast cancer is based on their complex toxicologic properties: organochlorines are able to influence estrogen-mediated and other en…