CareLit Fachartikel
Glucocorticoids reduce TGF-β Isoform 1, 2, 3 mRNA expression, TGF-β secretion and signaling in Hepatic Stellate Cells
L Wickert, U Bolkenius, M Abiaka, K Breitkopf, AM Gressner · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Dokument
1100667
CareLit-ID
Jahr
2004
Publikation
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Metadaten
DOI
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Zusammenfassung
Glucocorticoids regulates numerous physiological and pathophysiological responses. TGF-β signaling leads to the production of extracellular matrix proteins by activated hepatic stellate cells (HSC), which promote the development of liver fibrosis. Glucocorticoids and their receptors seem to interact with the TGF-β signaling pathway by antagonizing TGF-β effects. In this investigation we studied the influence of glucocorticoids on the TGF-β isoform mRNA and protein expression in transdifferentiating HSC using gene-specific real-time PCR and Elisa techniques. When HSC are seeded on plastic dishes they become spont…
Schlagworte
Corticosteroids
Hepatic Stellate Cells
TGF-β
Dexamethasone
Lead
After
Zeitschrift für Gastroenterologie
