CareLit Fachartikel
Functional Characterization of Naturally Occurring Mutations in the Human SLC21A8 Gene
K Letschert, D Keppler, J König · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Dokument
1100673
CareLit-ID
Jahr
2004
Publikation
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
The members of the organic anion transporting polypeptide (OATP) family are involved in the uptake of endogenous and xenobiotic substances into cells. Three OATP family members, OATP8, OATP2 or OATP-C, and OATP-B, have been localized to the basolateral membrane of human hepatocytes and are involved in the vectorial transport of organic anions from blood into bile. As determined in several expression systems, human OATP8 (symbol SLC21A8) transports bromosulfophthalein, dehydroepiandrosterone sulfate, cholecystokinin, and 17β-glucuronosyl estradiol. It has been anticipated that variants of the human OATP8 protein…
Schlagworte
organic anion transport
SLC21A8
OATP8
mutations
polymorphisms
Dehydroepiandrosterone Sulfate
Cholecystokinin
Cyclosporin
Population
Affect
Anions
Blood
Zeitschrift für Gastroenterologie
