CareLit Fachartikel
TGF-beta regulates the expression of TRAIL in hepatoma cells– regulation of programmed cell death in the liver
K Herzer · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Dokument
1100674
CareLit-ID
Jahr
2004
Publikation
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
TGF-beta is a pleiotropic cytokine that is involved in the development of liver cirrhosis and of tumors in different organs. TGF-beta suppresses the immune response and supports immune escape of certain tumors. Moreover, TGF-beta has been shown to induce apoptosis in normal or transformed hepatocytes. However, the mechanism by which apoptosis is induced is largely unknown. We examined whether death receptor-ligand systems play a role in TGF-beta induced apoptosis of hepatoma cells. We examined a potential role of various death receptor/ligand systems in TGF-beta-induced apoptosis and demonstrate, that the TNF-re…
Schlagworte
TRAIL
apoptosis
liver cells
tgf-beta
Cytokine
Zeitschrift für Gastroenterologie
