CareLit Fachartikel
Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein
S Urban, P Gripon · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Dokument
1100677
CareLit-ID
Jahr
2004
Publikation
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Metadaten
DOI
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Zusammenfassung
The interference with virus entry by peptides representing functional domains of viral envelope proteins is a key approach to the elucidation of entry mechanisms into respective host cells and for providing potential future antiviral therapies. Recently this approach lead to the identification of carboxypeptidase D as one receptor component of avian hepadnaviruses. However, due to the lack of an appropriate in vitro infection system this kind of analysis was not yet practicable for HBV. In our study, we took advantage of the newly-developed HBV-infectable cell line HepaRG (Gripon et al., PNAS, 99(24), 15655–1566…
Schlagworte
HBV infectable cell line
HBV-Entry inhibition
HBV-Receptor
Amino Acids
Cholesterol
Antibodies
Lead
After
Transplantation
Hepatitis
Zeitschrift für Gastroenterologie
