CareLit Fachartikel
CD8+ T cell tolerance induced by liver sinusoidal endothelial cells depends on ICOS/ICOSL interactions
L Diehl, G Wingender, A Hutloff, R Kroczek, S Porcelli, A Limmer, PA Knolle · Zeitschrift für Gastroenterologie · 2004 · Heft 02
Dokument
1100681
CareLit-ID
Jahr
2004
Publikation
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Zusammenfassung
The liver is know to have an immunological function and is involved in systemic peripheral tolerance. We have previously demonstrated that liver sinusoidal endothelial cells (LSEC), a new class of organ resident APC, can induce antigen specific T cell tolerance in vitro and in vivo. However, the molecular mechanisms underlying this observation remained unresolved. Here we show that the triggering of the inducible costimulator protein (ICOS) on CD8+ T cells by its ligand ICOSL on LSEC is involved for tolerance induction by LSEC, as ICOS-Ig fusion protein abrogated T cell tolerance induction in vitro. Additionally…
Schlagworte
Costimulation
Immunity
Liver Sinusoidal Endothelial Cells
T lymphocytes
Tolerance
Observation
Zeitschrift für Gastroenterologie
