Recipient-specific Immunosuppression by Donor-derived Suppressor Macrophages in porcine Lung Transplantation
M Strueber, G Warnecke, F Fändrich, SP Sommer, T Steinkamp, M Avsar, C Peters, R Reinhard, G Zehle, M Ruhnke, S Fischer, AR Simon, J Niedermeyer, A Haverich · Pneumologie · 2004 · Heft 03
Bibliografische Angaben
Zusammenfassung
Background: Isolated and M-CSF-stimulated donor macrophages induced indefinite rat heart allograft survival. This approach is to be evaluated in porcine lung transplantation. Methods: Lung transplantation from MHC mismatched donors was performed in 18 minipigs. Animals received 1–10×106 isolated, cultured (6 days) and M-CSF stimulated donor macrophages on POD0 (n=1), POD7 (n=5) or POD7 after 7Gy preoperative thymic and 1,5Gy whole body irradiation (n=6). Six animals served as controls. Immunosuppression included 1.5mg/kg/d methylprednisolone and 1.0mg/kg/d azathioprine. FK 506 was adjusted to 16–26 ng/ml. Immuno…
