Progesteron-induced blocking factor (PIBF): A potential novel tumour marker for screening and follow-up patients for gastrointestinal cancer
B Polgár, K Diófalvi, E Schäfer, K Oreskovich, T Gyökeres, J Hamvas, G Varga, Á Pap, R Schwab, J Szekeres-Bartho · Zeitschrift für Gastroenterologie · 2004 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: PIBF has been associated with maternal immune-tolerance and its role increasingly considered as a causative factor of diminished cellular immune defense (inhibition of NK cell cytolysis and influence on TH2 cytokine dominance over TH1) in neoplastic diseases. Human primary tumors and metastases are positive by immuno-histochemical staining with anti-PIBF antibodies. The level of PIBF in body fluids (blood and urine) has been found to correlate with the size of the tumor mass and seems to be suitable for monitoring therapeutic effectiveness and predicting relapse and tumor progression. Patients and me…
