Intestinal neurotransmitters and PARS activation in streptozotocin induced diabetic rats

Background and aims: Intrinsic and extrinsic intestinal innervation can be altered during diabetes. The purpose of our study was to compare the localization and density of different neurotransmitter containing nerve fibres in diabetic and control rats. Material and methods: Vasoactive intestinal polypeptide (VIP), substance P (SP), neuropeptide Y (NPY), tyrosine hydroxylase (TH), somatostatin (SOM), nitric oxide synthase (NOS) immunoreactive (IR) nerve fibres and poly (ADP-ribose) synthetase (PARS) IR immunocompetent cells were studied by immunohistochemistry in the intestine of Streptozotocin-induced diabetic r…