Different effect of clonidine on 2-deoxy-D-glucose-stimulated gastric motor function after central or peripheral administration in anesthetised rat

Introduction: Our previous findings suggested that α2-adrenoceptors are involved in mucosal protective processes. Since gastric motility may influence gastric mucosal defense the question was raised how activation of α2-adrenoceptors may influence gastric motor function. Method: Experiments were performed on male Wistar rats anesthetized by urethane (1.25mg/kg, intraperitoneal). Gastric motility was measured using a rubber balloon inserted into the stomach via mouth. Drugs were given intracerebroventricularly (icv.) or intravenously (iv.). Results: 1. Clonidine (0.75–3.76 nmol/kg) after iv. administration inhibi…