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Reprogramming of neuroblastoma cells by the histone deacetylase inhibitor valproic acid

H Deubzer, J Schulte, L Schweigerer, J Hoheisel, O Witt · Klinische Pädiatrie · 2004 · Heft 05

Dokument
1101098
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
H Deubzer, J Schulte, L Schweigerer, J Hoheisel, O Witt
Ausgabe
Heft 05 / 2004
Seiten
–
Erschienen: 2004-05-27 00:00:00
ISSN
0300-8630
DOI
10.1055/s-2004-828557

Zusammenfassung

Spontaneous and therapy-induced differentiation is one of the biological hallmarks of childhood neuroblastomas. The degree of differentiation towards ganglionic cells is recognized as the principal morphological feature to be of prognostic importance. We hypothesized that neuroblastoma cells contain a differentiation program, which can be activated either pharmacologically or by unknown endogenous mechanisms. The histone deacetylase (HDAC) inhibitor valproic acid (VPA) induces morphological features of ganglionic differentiation in 4 neuroblastoma cell lines and inhibited HDACs in all cell lines studied. Using c…

Schlagworte

Differentiation Neuroblastoma Cells Valproic Morphological Histone Deacetylase Inhibitor Neuroblastomas Towards Ganglionic Program Klinische Pädiatrie